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Nanoemulsion (~50 nm, confirmed by DLS) is one of the most advanced ways to improve the bioavailability of polyphenols.
In modern supplementation, one key question keeps returning:
Why do powerful compounds such as curcumin or resveratrol perform far below what laboratory studies suggest?
In most cases, the answer is simple:
it’s not about the dose — it’s about bioavailability.
Polyphenols such as xanthohumol, curcumin, quercetin, and resveratrol are among the most extensively studied compounds with antioxidant potential and support for physiological balance.
At the same time, they share a key limitation:
very low water solubility (hydrophobic nature).
In practice, this means:
Our formulations were analyzed using Dynamic Light Scattering (DLS), a method that determines the actual particle size in solution.
You can read more about the underlying mechanism here:
What are liposomes and how they work
Below are the actual results of the laboratory analysis (DLS):
DLS (Dynamic Light Scattering) analysis results for xanthohumol nanoemulsion – average particle size: 48.21 nm, PdI: 0.206. Quality result: good.
Dynamic Light Scattering (DLS) test results for a xanthohumol nanoemulsion developed by Green Hemp Poland show:
The following parameters were obtained:
The technological process includes controlled homogenization and stabilization of the lipid system, allowing the creation of a stable nanoemulsion with reproducible parameters.
Achieving the correct particle size is only the first step.
The key factor is whether the system remains stable over time.
The described xanthohumol formulation is also available as a finished product, prepared to order using liposomal nanoemulsion technology:
Xanthohumol liposomal
One of the main challenges in nanoemulsion technology is not only achieving the desired particle size, but also maintaining stability over time.
The system was analyzed using the Turbiscan Stability Index (TSI), which evaluates destabilization kinetics and structural changes in the formulation.
Stability test results:
Nanoemulsion Stability Study (TSI – Turbiscan Stability Index) – analysis of system changes over time.
Interpretation:
System stability is a key factor influencing both the repeatability of performance and the quality of the final product.
The nanoemulsions are designed for sublingual administration, which significantly changes how active compounds are delivered in the body:
Combined with a particle size of ~50 nm, this can significantly enhance the efficiency of active compound utilization.
A more detailed explanation of bioavailability mechanisms can be found here:
Liposomal curcumin – bioavailability, effects and comparison with infusions
Green Hemp Poland formulations are developed with the goal of combining multiple polyphenols within a single liposomal system.
Currently, we work on individual compounds separately, optimizing:
In later stages, more complex formulations are planned, combining:
This approach allows for full control over each component, and in the next step, enables the development of synergistic systems.
The obtained parameters (~48 nm / PdI ~0.2) and stability results confirm a high level of technological precision and formulation quality.
This reflects the direction of modern supplementation:
not by increasing the dose, but by optimizing the delivery system.
The technology described in this article is applied in specific formulations developed by Green Hemp Poland.
Explore available products:
Formulations and products
See collaboration and production opportunities:
LiposomeFactory
Green Hemp Poland
Hubert Pyrgiel
Innovation based on technology and nature.
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